Arrhythmias & electrophysiology
Left Bundle Branch Area Defibrillator (LBBA Defibrillator (LBBAD))): A First-in-Human Feasibility Study
Authors' conclusion
This first-in-human evaluation showed the feasibility of LBBAD implantation in a small cohort of patients.
Study context
- Population
- Patients with an implantable cardioverter-defibrillator (ICD) indicationimplantation achieved in 3
- Participants
- 5 patients
- Outcome
- Safety and feasibility of implanting an LBBA ICD lead
Methodological detailssingle-centre, first-in-human
- Single-centre
- First-in-human
Main finding
As reported in the abstract
Successful LBBAD implantation
LBBAD
60%
3 of 5
Observational data: associations, not effects.
Further findings
Procedural and fluoroscopy duration
- Mean procedural duration
- 170.0 ± 17.3 minutes
- Mean fluoroscopy duration
- 28.8 ± 16.1 minutes
Capture type
- Left bundle capture
- 2 patients (66%)
- Left septal capture
- 1 patient
Paced ECG (left bundle branch area (LBBA) pacing)
- Mean QRS duration
- 121.3 ± 8.3 milliseconds
- Mean V6 R-wave peak time
- 86.1 ± 10.0 milliseconds
Defibrillation testing
- Successful defibrillation testing
- 3
- Mean time to adequate shock delivery
- 8.6 ± 2.6 seconds
- All 3 patients
Acute LBBA pacing parameters
- Pacing threshold
- 0.80 ± 0.60 V at 0.4 milliseconds
- R-wave amplitude
- 7.0 ± 2.7 mV
Safety
- No LBBA lead-related complications
Original publication
Left Bundle Branch Area Defibrillator (LBBAD)): A First-in-Human Feasibility Study. JACC Clin Electrophysiol. Published 22 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →