Prevention & lipidsCohort study
Left Main Coronary Artery Calcium and Diabetes Confer Very-High-Risk Equivalence in Coronary Artery Calcium >1,000
- Cohort study
- Coronary artery calcium (CAC) Consortium
- Cox proportional hazards regression
Mean age 66.6 years, 14% female, 10% non-White; median CAC 1,592; 6% severe left main (LM) CAC
Authors' conclusion
Among asymptomatic patients with a CAC of ≥1,000 without a prior index event, diabetes, and severe LM CAC define very high risk ASCVD
Study context
- Population
- Asymptomatic patients with CAC ≥1,000 without prior atherosclerotic cardiovascular disease (ASCVD) event, CAC Consortium
- Participants
- 2,246 patients
- Exposure
- Risk factors for ASCVD mortality in CAC ≥1,000
- Alln = 2,246reference
- Outcome
- ASCVD mortality (very high risk benchmark: 1.4 per 100 person-years)
- Follow-up
- Median 11.3 years
Main finding
As reported in the abstract
ASCVD mortality
Each group vs allHazard ratio (95% CI)
Diabetes
2.04(1.47–2.83)
Severe LM CAC
2.32(1.51–3.55)
Observational data: associations, not effects.
Original publication
Left Main Coronary Artery Calcium and Diabetes Confer Very-High-Risk Equivalence in Coronary Artery Calcium >1,000. JACC Cardiovasc Imaging. Published 21 February 2024. doi:10.1016/j.jcmg.2023.12.006
Summarised from the published abstract; every number is checked against it