Heart failure & cardiomyopathies
Left ventricular anatomy in obstructive hypertrophic cardiomyopathy: beyond basal septal hypertrophy
Authors' conclusion
LV anatomy underpinning oHCM consists of basal septal hypertrophy, apical dilatation, LV lengthening, and LVOT inward remodelling.
Study context
- Population
- Individuals with HCM in the NHLBI HCM Registry with CMR imagingNHLBI HCM Registry
- Participants
- 2,398 individuals
- Exposure
- Obstructive vs non-obstructive HCM
- Outcome
- LV end-diastolic morphology associated with LVOT obstruction
Methodological detailsstatistical shape model, principal component analysis, linear discriminant analysis
- Statistical shape model
- Principal component analysis
- Linear discriminant analysis
Main finding
As reported in the abstract
LV remodelling pattern in oHCM
- Left ventricular (LV) remodelling in obstructive hypertrophic cardiomyopathy (oHCM): basal septal hypertrophy combined with LV lengthening, apical dilatation and LVOT inward remodelling
Observational data: associations, not effects.
Further findings
Obstruction at rest vs stress
- Salient differences between obstructive cases at rest and stress
Phenotype by genotype
- Genotype-negative cases tended towards more obstructive phenotypes at rest and stress
Original publication
Left ventricular anatomy in obstructive hypertrophic cardiomyopathy: beyond basal septal hypertrophy. Eur Heart J Cardiovasc Imaging. Published 28 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →