Valvular & structural heart disease
Left ventricular dilatation in patients with significant aortic regurgitation: association with outcome
Authors' conclusion
In patients with significant AR, the presence of LV dilatation detected by linear and/or volumetric measures was independently associated with increased mortality.
Study context
- Population
- Patients with significant aortic regurgitation (AR)56 ± 18 years, 65% male
- Participants
- 1,070 patients
- Comparison
- Discordant or concordant left ventricular (LV) dilatation compared with patients with no-significant LV dilatation
- no-significant LV dilatationn = 485reference
- discordant LV dilatationn = 279
- concordant LV dilatationn = 306
- Outcome
- All-cause mortality
- Follow-up
- Median 7.4 (IQR, 4.5-11) years
Main finding
As reported in the abstract
All-cause mortality
Each group vs no-significant LV dilatationHazard ratio (95% CI)P value
Discordant LV dilatation
2.066(1.295–3.298)
P = 0.002Concordant LV dilatation
2.759(1.616–4.710)
P < 0.001- Died
- 168 patients (16%)
- Concordant LV dilatation showed the worst 10-year survival
- P < 0.001
Further findings
Aortic valve surgery (AVS) · median follow-up of 7.4 (IQR, 4.5-11) years
- Underwent AVS
- 484 (45%)
- Both discordant and concordant groups showed greater benefit from AVS
Outcome in asymptomatic patients and those with LVEF > 55% (subgroups)
- LV dilatation, either concordant or discordant, independently associated with outcome
Original publication
Left ventricular dilatation in patients with significant aortic regurgitation: association with outcome. Eur Heart J Cardiovasc Imaging. Published 5 June 2025. doi:10.
Summarised from the published abstract; every number is checked against it