Heart failure & cardiomyopathiesCohort study
Left Ventricular Dysfunction Associated With Brain Death: Results From the Donor Heart Study
- Prospective cohort study
- multisite
Authors' conclusion
LV dysfunction associated with brain death occurs in many potential heart donors and is sometimes reversible.
Study context
- Population
- Potential heart donors by neurologic determination of death, 8 organ procurement organizations, US, February 2015–May 20203,794 with initial TTE
- Participants
- 4,333 donors
Main finding
As reported in the abstract
LV dysfunction on initial TTE
Left ventricular (LV) dysfunction
493 (13%)
Observational data: associations, not effects.
Further findings
| Outcome | Normal LV function | Reversible LV dysfunction | Nonreversible LV dysfunction |
|---|---|---|---|
| Donor heart acceptance for transplant | Sixty percent | 56% | 24% |
Reversibility of LV dysfunction on second TTE · 24±6 hours
- Reversible LV dysfunction among donors with second TTE (n=224)
- 130 (58%)
Factors associated with LV dysfunction
- LV dysfunction associated with younger age, underweight, and higher NT-proBNP and troponin levels
Recipient 1-year survival
- Donor LV dysfunction, reversible or not, not associated with recipient 1-year survival
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Left Ventricular Dysfunction Associated With Brain Death: Results From the Donor Heart Study. Circulation. Published 19 July 2023. doi:10.1161/circulationaha.122.063400
Summarised from the published abstract; every number is checked against it