Valvular & structural heart diseaseCohort study
Left Ventricular Ejection Fraction and Benefit of Tricuspid Valve Interventions – Insights from the International TRIGISTRY
- Registry-based cohort study (TRIGISTRY)
- multicentre
- international registry
Authors' conclusion
Transcatheter tricuspid valve intervention, whether surgical or transcatheter-based, was associated with improved survival in patients with pEF but not in those with mrEF or rEF. Residual TR remained a significant prognostic factor across the entire LVEF spectrum.
Study context
- Population
- Patients with severe isolated tricuspid regurgitation (TR), by LVEF: pEF ≥50%, mrEF 41–49%, rEF ≤40%pEF ≥50% 1,383 · mrEF 41-49% 400 · rEF ≤40% 601
- Participants
- 2,384 patients
- Exposure
- Surgery or transcatheter tricuspid valve interventions (TTVI) vs conservative management, by LVEF category
- Outcome
- Survival by treatment modality and procedural success within each LVEF category
- Follow-up
- 2 years
Main finding
As reported in the abstract
2-year survival vs conservative management, by LVEF category
- Surgery vs Conservative: P < 0.0005
- TTVI vs Conservative: P < 0.0001
- Surgery vs Conservative: P = 0.28
- TTVI vs Conservative: P = 0.28
- Surgery vs Conservative: P = 0.76
- TTVI vs Conservative: P = 0.22
Observational data: associations, not effects.
Further findings
2-year survival, surgical and transcatheter interventions grouped vs conservative
- pEF
- P < 0.0001
- mrEF
- P = 0.17
- rEF
- P = 0.29
Survival with residual TR after TTVI vs conservative
- Trend toward worse survival, pEF
- P = 0.47
- Trend toward worse survival, mrEF
- P = 0.33
- Worse survival, rEF
- P = 0.008
Original publication
Left Ventricular Ejection Fraction and Benefit of Tricuspid Valve Interventions – Insights from the International TRIGISTRY. Eur J Heart Fail. Published 30 August 2025. doi:10.1002/ejhf.3797
Summarised from the published abstract; every number is checked against it