Heart failure & cardiomyopathies
Left ventricular ejection fraction and long-term outcomes in women presenting with signs and symptoms of ischaemia
Authors' conclusion
Among women with suspected ischaemia, women with LVEF above the defined normal threshold (>65%) had lower rates of all-cause mortality and non-fatal MI.
Study context
- Population
- Women presenting with suspected myocardial ischaemia (Women's Ischemia Syndrome Evaluation (WISE)); Left ventricular ejection fraction (LVEF) by invasive left ventriculographyanalysed
- Participants
- 734 women
- Exposure
- High vs normal vs low LVEF
- Outcome
- Long-term all-cause mortality and MACE
Methodological detailsanalysis of the WISE cohort, multivariable Cox regression
- Analysis of the WISE cohort
- Multivariable Cox regression
Main finding
As reported in the abstract
All-cause mortality and MACE
- Low LVEF vs Normal LVEF and High LVEF: P < 0.0001
- Normal LVEF vs High LVEF: P = 0.047
- Low LVEF vs High LVEF: P = 0.013
- Normal LVEF vs High LVEF: P = 0.16
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| MINormal LVEF vs High LVEF · higher MI rate with normal LVEF | P = 0.03 |
Original publication
Left ventricular ejection fraction and long-term outcomes in women presenting with signs and symptoms of ischaemia. Heart. Published 14 June 2023. doi:10.
Summarised from the published abstract; every number is checked against it