Valvular & structural heart diseaseSecondary analysis
Left Ventricular Ejection Fraction in Patients Undergoing Transcatheter Aortic Valve Implantation
- substudy
- all-comer
- randomized 1:1
Authors' conclusion
TAVI improves LVEF in the majority of patients with low baseline LVEF. However, a subset of patients experiences persistent left ventricular impairment, with chronic heart failure, pacemaker, and baseline LVEF as key predictors.
Study context
- Population
- Patients scheduled for transfemoral TAVI in the COMPARE-TAVI 1 trialmen comprised 60%
- Participants
- 1,029 patients
- Comparison
- Low baseline LV ejection fraction (LVEF) vs normal baseline LVEF
- low LVEFn = 151
Primary result
As reported in the abstract
Mean LVEF (all patients) · baseline
mean LVEF
55% ± 14%
Further findings
| Outcome | low LVEF | normal LVEF |
|---|---|---|
| LVEF ≤40% at 1 year | persistent LVEF ≤40% 20% | declined to ≤40% 5% |
Mean LVEF among patients with low baseline LVEF · 1 month and 12 months
- baseline
- 31% ± 6%
- 1 month
- 45% ± 15%
- 12 months
- 52% ± 14%
- P
- P < 0.001
Variables associated with persistent low LVEF · 1 year
- Chronic heart failure, pacemaker pre-TAVI, baseline LVEF, left ventricular end-diastolic diameter, aortic mean gradient, and stroke volume index were associated with persistent low LVEF
1-year mortality
- No significant differences between groups
Original publication
Left Ventricular Ejection Fraction in Patients Undergoing Transcatheter Aortic Valve Implantation. JACC Adv. Published 24 January 2026. doi:10.1016/j.jacadv.2025.102547
Summarised from the published abstract; every number is checked against it