Left Ventricular Ejection Fraction Trajectory and Long-Term Outcomes Following Percutaneous Coronary Intervention for Myocardial Infarction
Authors' conclusion
LVEF trajectory after MI significantly impacts long-term outcomes. Even patients with LVEF recovery remain at increased risk for heart failure hospitalization and mortality compared to those with pEF.
Study context
- Population
- Patients undergoing percutaneous coronary intervention (PCI) for myocardial infarction (MI) (2007–2022) with serial echocardiogramsmean age 64 ± 10 years, 24.5% female, 46.8% ST-segment elevation MI
- Participants
- 13,439 patients
- Exposure
- Left ventricular ejection fraction (LVEF) trajectory groups compared to pEF
- Outcome
- Heart failure hospitalization
- Follow-up
- Within 6 years
Methodological detailsSwedish Coronary Angiography and Angioplasty Registry and UC San Diego internal National Cardiovascular Data Registry CathPCI Registry, time-to-event analysis adjusted for baseline characteristics
- Swedish Coronary Angiography and Angioplasty Registry and UC San Diego internal National Cardiovascular Data Registry CathPCI Registry
- Time-to-event analysis adjusted for baseline characteristics
Main finding
As reported in the abstract
Adjusted hazard ratio (95% CI)P value
redEFvs pEF
8.49(7.49–9.64)
P < 0.001decEFvs pEF
5.74(4.69–7.02)
P < 0.001recEFvs pEF
3.18(2.70–3.76)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | redEF | recEF | pEF | decEF | aHR (95% CI) | P value | |
|---|---|---|---|---|---|---|---|
| All-cause mortality · within 6 yearsredEFvs pEF | 14.0% | 7.8% | 6.7% | 14.9% | 2.20 (1.86–2.59) | P < 0.001 | |
| All-cause mortality · within 6 yearsdecEFvs pEF | 2.10 (1.56–2.82) | P < 0.001 | |||||
| All-cause mortality · within 6 yearsrecEFvs pEF | 1.30 (1.02–1.65) | P = 0.032 | |||||
| 0.20.5125Adjusted hazard ratio (log scale) |
- All-cause mortality: across groups P < 0.001
Original publication
Left Ventricular Ejection Fraction Trajectory and Long-Term Outcomes Following Percutaneous Coronary Intervention for Myocardial Infarction. JACC Adv. Published 18 June 2026. doi:10.
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