Arrhythmias & electrophysiologyRandomised controlled trial
Left Ventricular Entry to Reduce Brain Lesions During Catheter Ablation: A Randomized Trial
- Randomised controlled trial
- multicentre
- comparative effectiveness
Authors' conclusion
Among patients undergoing left ventricular catheter ablation procedures, a transseptal approach reduced the risk of acute brain lesions by nearly half compared with a retrograde aortic approach without sacrificing safety or efficacy.
Study context
- Population
- Patients with left ventricular arrhythmias undergoing catheter ablationwith postoperative brain MRI
- Participants
- 69 vs 62
- Comparison
- Transseptal puncture vs retrograde aortic approach for LV entry
- Transseptaln = 69
- Retrograde aorticn = 62reference
- Primary endpoint
- Acute brain lesion detected by MRI
Primary result
As reported in the abstract
Acute brain lesion on MRI
P = 0.036
Secondary outcomes
High likelihood of cognitive impairment · 6 months · substantial loss to follow-up
Procedural efficacy
- No differences in procedural efficacy
Safety
Clinically manifest complications
- No differences in clinically manifest complications
Original publication
Left Ventricular Entry to Reduce Brain Lesions During Catheter Ablation: A Randomized Trial. Circulation. Published 24 February 2025. doi:10.1161/circulationaha.124.071352
Summarised from the published abstract; every number is checked against it