Heart failure & cardiomyopathies
Left Ventricular Filling Pressure Classification by Electrocardiogram, Echocardiography, and Catheterization
- Retrospective cohort study
Authors' conclusion
Despite moderate agreement with PAWP, echocardiography and AI-ECG showed stronger associations with clinical outcomes, suggesting they capture prognostically relevant myocardial information beyond resting hemodynamic status.
Study context
- Population
- Adults who underwent echocardiography with electrocardiography within 14 days and right heart catheterization (RHC) within 30 daysmedian age: 64 years, 47.7% women
- Participants
- 4,168 adults
- Exposure
- LVFP classification by AI-ECG, echocardiography, and pulmonary artery wedge pressure (PAWP)
- AI-ECGn = 2,383
- Echocardiographyn = 1,643
- PAWPn = 1,841
Main finding
As reported in the abstract
Discrimination of AI-ECG for echocardiographic LVFP
AUC
0.879; 95% CI: 0.867-0.891
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| All-cause mortality · Over 7.7 years — Elevated LVFP by AI-ECG vs not elevated | 1.80 (1.55–2.09) | |
| All-cause mortality · Over 7.7 years — Elevated LVFP by echocardiography vs not elevated | 1.74 (1.51–2.02) | |
| All-cause mortality · Over 7.7 years — Elevated LVFP by PAWP vs not elevated | 1.18 (1.05–1.31) | |
| 0.512Adjusted hazard ratio (log scale) |
- All-cause mortality — Deaths
- 1,433
Discrimination of AI-ECG for PAWP
- AUC
- 0.711; 95% CI: 0.695-0.727
- Moderate discrimination
All-cause mortality · Over 7.7 years
- In discordant cases, AI-ECG better predicted survival
Major adverse cardiovascular events
- Similar associations were observed
Original publication
Left Ventricular Filling Pressure Classification by Electrocardiogram, Echocardiography, and Catheterization. JACC Cardiovasc Imaging. Published 12 October 2026. doi:10.
Summarised from the published abstract; every number is checked against it