Valvular & structural heart disease
Left Ventricular Function and Atrial Remodeling Shape Outcomes After Mitral-Transcatheter Edge-to-Edge Repair
Authors' conclusion
M-TEER provides sustained clinical benefit across the LVEF spectrum, including patients with preserved LVEF. Left atrial enlargement identifies patients with worse prognosis and may represent a marker of advanced atrial disease supporting earlier intervention.
Study context
- Population
- Patients with symptomatic secondary mitral regurgitation (SMR) treated with mitral transcatheter edge-to-edge repair (M-TEER) between 2018 and 202287 patients with complete follow-up
- Participants
- 93 patients
- Comparison
- Patients were stratified according to left ventricular ejection fraction (LVEF) and left atrial volume index
- Outcome
- comprehensive clinical improvement, defined as survival without heart-failure hospitalization, New York Heart Association (NYHA) class I-II, and Kansas City Cardiomyopathy Questionnaire (KCCQ) score >60
- Follow-up
- 36 months
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
- Achieved the composite endpoint, among 87 patients with complete follow-up
- 48 (55%)
Further findings
| Outcome | Reduced LVEF | Preserved LVEF | LAVI <60 mL/m² | LAVI ≥60 mL/m² | |
|---|---|---|---|---|---|
| All-cause mortality · 36 months | 29.6% | 9.4% | Not reported in the abstract | Not reported in the abstract | LAVI <60 mL/m², LAVI ≥60 mL/m²: not reported in the abstract |
| Mortality by LAVI | Not reported in the abstract | Not reported in the abstract | 11.8% | 29.4% | reduced LVEF, preserved LVEF: not reported in the abstract |
- All-cause mortality: lower in preserved LVEF; log-rank p=0.03
- Mortality by LAVI: increased mortality with LAVI ≥60 mL/m²; log-rank p=0.04
Mortality by LAVI
- In Cox regression adjusted for age and sex, LAVI remained associated with mortality risk
Original publication
Left Ventricular Function and Atrial Remodeling Shape Outcomes After Mitral-Transcatheter Edge-to-Edge Repair. ESC Heart Fail. Published 22 May 2026. doi:10.
Summarised from the published abstract; every number is checked against it