Valvular & structural heart diseaseCohort study
Left ventricular global longitudinal strain improves risk stratification in chronic aortic regurgitation
- retrospective cohort study
Authors' conclusion
In NYHA class I-II patients with chronic moderate-to-severe AR, FT-LVGLS was independently associated with MACE and provided incremental prognostic value beyond ESC/EACTS guideline-based surgical indication parameters, supporting its potential role in improving risk identification.
Study context
- Population
- Patients with chronic moderate to severe aortic regurgitation (AR) with no or minimal symptoms (NYHA class I–II) who underwent cardiac magnetic resonance (CMR) between 2010 and 2024primary study cohort (NYHA class I–II), of 707 patients initially screened, mean age 54.1 ± 13.5 years, 329 male
- Participants
- 385 patients
- Exposure
- Prognostic models containing each ESC/EACTS Class I/IIb surgical indication parameter with vs without FT-LVGLS
- Outcome
- MACE:
- All-cause mortality
- Heart transplantation
- Unplanned hospitalization for heart failure
- Implantable cardioverter defibrillator discharge
- Follow-up
- Median 52.9 months
Main finding
As reported in the abstract
Adjusted hazard ratio
1.210
P < 0.007
- Patients experiencing major adverse cardiac events (MACE)
- 45
Observational data: associations, not effects.
Further findings
Model discrimination for MACE after adding FT-LVGLS to models with each ESC/EACTS Class I/IIb surgical indication parameter
- C-index without FT-LVGLS
- 0.730-0.768
- C-index with FT-LVGLS
- 0.783-0.791
- Likelihood ratio χ2 without FT-LVGLS
- 36.04-41.12
- Likelihood ratio χ2 with FT-LVGLS
- 50.10-52.07
- parameters dichotomized by guideline-recommended thresholds
Risk stratification by absolute FT-LVGLS cut-off (Kaplan-Meier)
- Absolute FT-LVGLS cut-off further refined risk stratification
- 12%
Original publication
Left ventricular global longitudinal strain improves risk stratification in chronic aortic regurgitation. Eur Heart J Cardiovasc Imaging. Published 2 June 2026. doi:10.1093/ehjci/jeag135
Summarised from the published abstract; every number is checked against it