Arrhythmias & electrophysiologyResearch article
Left Ventricular Late Gadolinium Enhancement for Arrhythmic Risk Prediction in Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
- Survival analyses
- 17 centers
- Cox proportional hazard models
- sensitivity analysis of high-risk late gadolinium enhancement (LGE)
Authors' conclusion
While associated with the risk of VA in ARVC, LV LGE did not provide incremental prognostic value for incident VA risk prediction compared with the ARVC risk calculator.
Study context
- Population
- Patients with definite ARVC, no prior sustained ventricular arrhythmia (VA), and contrast-enhanced cardiac magnetic resonance at baseline132 (34.3%) had left ventricular (LV) LGE, 98 (25.5%) high-risk pattern
- Participants
- 385 patients
- Comparison
- incremental prognostic value of LV LGE on the risk calculator
- LV LGEn = 132
- high-risk LV LGEn = 98
Main finding
As reported in the abstract
Sustained VA · 3.1 [1.2-5.8] years of follow-up
patients experienced VA
67 (17.4%)
Further findings
| Outcome | hazard ratio | P value |
|---|---|---|
| VA, univariable analysis — LV LGE · higher risk for VA | 1.82 | P = 0.014 |
| VA, univariable analysis — high-risk LV LGE · higher risk for VA | 1.85 | P = 0.017 |
Sustained VA, adjusted for ARVC calculator-estimated risk
- LV LGE did not independently predict sustained VA
- P = 0.85
- high-risk LV LGE did not independently predict sustained VA
- P = 0.87
Original publication
Left Ventricular Late Gadolinium Enhancement for Arrhythmic Risk Prediction in ARVC. Circ Arrhythm Electrophysiol. Published 29 January 2026. doi:10.1161/circep.125.014265
Summarised from the published abstract; every number is checked against it