Left Ventricular Noncompaction in Childhood: Echocardiographic Follow-Up and Prevalence in First-Degree Relatives
Authors' conclusion
At 2 to 4 years, children with LVNC diagnosed at birth had reduced systolic function compared to children without but did not have progression of LV dysfunction or extent of trabeculations. In first-degree relatives to children with LVNC, 30% fulfilled criteria.
Study context
- Population
- 2 to 4-year-old children with and without left ventricular noncompaction (LVNC) at birth, and their first-degree relatives14 of 16 children with LVNC included
- Participants
- 14 / 56 / 37 / 146
- Exposure
- Children with vs without LVNC at birth; their first-degree relatives
- LVNCn = 14
- No LVNCn = 56reference
- Relatives of LVNCn = 37
- Relatives of no LVNCn = 146reference
- Outcome
- Changes in LV function and morphology; prevalence of LVNC in first-degree relatives
- Follow-up
- 2 to 4 years
Methodological detailsblinded LVNC assessment
- Blinded LVNC assessment
Main finding
As reported in the abstract
| Group | Value | Trabeculation, birth vs follow-up | LVEF, birth vs follow-up | Fulfilled LVNC criteria |
|---|---|---|---|---|
| LVNC | 49% | 8% vs 13% | 50% vs 49% | |
| No LVNC | 60% | |||
| Relatives of LVNC | 30% | 11 of 37 (30%) |
Value
LVNC49%
No LVNC60%
Relatives of LVNC30%
Trabeculation, birth vs follow-up
LVNC8% vs 13%
No LVNC— not stated in the abstract
Relatives of LVNC— not stated in the abstract
LVEF, birth vs follow-up
LVNC50% vs 49%
No LVNC— not stated in the abstract
Relatives of LVNC— not stated in the abstract
Fulfilled LVNC criteria
LVNC— not stated in the abstract
No LVNC— not stated in the abstract
Relatives of LVNC11 of 37 (30%)
- LVNC vs No LVNC: P < 0.001 — LVEF at follow-up
- LVNC: P = 0.81 — trabeculation, birth vs follow-up
- LVNC: P = 0.91 — LVEF, birth vs follow-up
- Relatives of LVNC vs Relatives of no LVNC: P < 0.001 — fulfilled LVNC criteria
Observational data: associations, not effects.
Original publication
Left Ventricular Noncompaction in Childhood: Echocardiographic Follow-Up and Prevalence in First-Degree Relatives. JACC Adv. Published 10 February 2024. doi:10.
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