Acute cardiac care & resuscitation
Left ventricular outflow tract obstruction in Takotsubo syndrome with cardiogenic shock: prognosis and treatment
Authors' conclusion
LVOTO is not uncommon in patients with TTS and cardiogenic shock. It is associated with a more aggressive in-hospital course and our data is unable to rule out an association between the presence of LVOTO and long-term prognosis of patients with TTS.
Study context
- Population
- Patients with Takotsubo syndrome and cardiogenic shock during admission, multicentre registry, 2003–2022
- Participants
- 322 patients
- Exposure
- Left ventricular outflow tract obstruction (LVOTO) vs no LVOTO
- LVOTOn = 58
- Outcome
- All-cause death (cumulative incidence)
- Follow-up
- 90 days and 5 years
Methodological detailsmulticentre registry
- Multicentre registry
Main finding
As reported in the abstract
LVOTO vs No LVOTOHazard ratio (95% CI)
90 days
1.20(0.60–2.40)
5 years
1.69(0.89–3.21)
Observational data: associations, not effects.
Further findings
Use of vasoactive and inotropic therapy (VIT)
P < 0.001
Safety
Development or worsening of obstruction with VIT
In-hospital complications
Ventricular arrhythmias
P = 0.017
Major bleeding
P = 0.042
Acute kidney failure
P = 0.003
Original publication
Left ventricular outflow tract obstruction in Takotsubo syndrome with cardiogenic shock: prognosis and treatment. Heart. Published 28 August 2024. doi:10.
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