Heart failure & cardiomyopathiesCohort study
Left ventricular recovery and outcomes in patients with a durable left ventricular assist device: the EUROMACS registry
- Registry-based cohort study
- multicentre
Authors' conclusion
This multicentre European study shows that LV recovery mostly occurs within the first year after LVAD implantation and is associated with better clinical outcomes.
Study context
- Population
- Patients with a durable left ventricular assist device (LVAD) with left ventricular ejection fraction (LVEF) measured at baseline and after implantation (EUROMACS registry)
- Participants
- 1,550 patients
- Exposure
- No recovery vs Mild vs Intermediate vs Full
- Outcome
- Prevalence, predictors and clinical impact of LV recovery after LVAD implantation
Main finding
As reported in the abstract
Marginal probability of LV recovery category · 4 years
Observational data: associations, not effects.
Further findings
Predictors of any left ventricular (LV) recovery
| Comparison | HR (95% CI) | |
|---|---|---|
| Renin-angiotensin system inhibitor use | 1.17 (1.00–1.37) | |
| 0.512Hazard ratio (log scale) |
| Outcome | HR |
|---|---|
| Predictors of any LV recovery — INTERMACS Class 2 vs INTERMACS Class 1 | .72 |
| Predictors of any LV recovery — INTERMACS Class 3 vs INTERMACS Class 1 | .64 |
| Predictors of any LV recovery — INTERMACS Class 4 vs INTERMACS Class 1 | .51 |
| All-cause mortality per 10% higher LVEF during follow-up · CrI | .86 (95% CI .75-.98) |
- All-cause mortality per 10% higher LVEF during follow-up: 95% credible interval
MACE (CV death, late right HF, arrhythmia) beyond the first year, by LV recovery category at 1 year
- Cumulative incidence lower across higher LV recovery categories (Gray's test)
- P = 0.042
Original publication
Left ventricular recovery and outcomes in patients with a durable left ventricular assist device: the EUROMACS registry. Eur Heart J. Published 9 July 2026. doi:10.1093/eurheartj/ehag477
Summarised from the published abstract; every number is checked against it