Heart failure & cardiomyopathiesCohort study
Left ventricular septal pacing combined with left ventricular pacing improves acute electric resynchronization, hemodynamic responses and clinical outcomes: results of SPORT study
- Prospective observational study
- consecutive patients
Authors' conclusion
LVSP combined with LVP might offer greater AHR, electrical resynchronization and as well as improved clinical outcomes than LVSP alone in patients undergoing LBBAP-CRT without LBB capture.
Study context
- Population
- Patients undergoing LBBAP-CRT without confirmed LBB capture
- Participants
- 45 patients
- Exposure
- Left ventricular septal pacing (LVSP) + LVP vs LVSP alone
- LVSP + LVPn = 20
- LVSPn = 25reference
Main finding
As reported in the abstract
QRS duration (QRSd) reduction
P = 0.049
Observational data: associations, not effects.
Further findings
Improvement in AHR (LV dP/dtmax)
P＜0.001
| Outcome | mean difference (%) (95% CI) | P value | |
|---|---|---|---|
| LVEF improvement · median follow-up 26 months | 3.05 (0.05–6.05) | P = 0.047 | |
| −50510Difference, % (linear scale) |
| Outcome | aHR (CI) | P value | |
|---|---|---|---|
| Clinical outcomes (all-cause mortality, HF hospitalization, ventricular tachyarrhythmias) · median follow-up 26 months · 87% lower risk | 0.13 (0.03–0.62) | P = 0.011 | |
| 0.050.21520Adjusted hazard ratio (log scale) |
- Improvement in acute hemodynamic response (AHR) (LV dP/dtmax): in 10 patients
Original publication
Left ventricular septal pacing combined with left ventricular pacing improves acute electric resynchronization, hemodynamic responses and clinical outcomes: results of SPORT study. Europace. Published 4 August 2025. doi:10.1093/europace/euaf147
Summarised from the published abstract; every number is checked against it