Acute cardiac care & resuscitationRandomised controlled trial
Left Ventricular Unloading in High-Risk Percutaneous Coronary Intervention
- Randomised controlled trial
Authors' conclusion
Among patients with severely impaired left ventricular function undergoing complex PCI, elective left ventricular unloading with a microaxial flow pump did not reduce the risk of major adverse clinical outcomes at a minimum of 12 months.
Study context
- Population
- Patients with severe LV dysfunction and extensive CAD undergoing planned complex percutaneous coronary intervention (PCI)
- Participants
- 300 patients
- Comparison
- Microaxial flow pump vs Standard care
- Microaxial flow pumpn = 148
- Standard caren = 152reference
- Primary endpoint
- Hierarchical composite of:
- All-cause death
- Disabling stroke
- Spontaneous MI
- CV hospitalization
- Periprocedural myocardial injury
- Follow-up
- Minimum of 12 months
Primary result
As reported in the abstract
median 22 months (IQR 16 to 30)
Win ratio
0.85
95% CI 0.63–1.15
P = 0.30
By group
Microaxial flow pump vs Standard care
win ratio 0.85 (95% CI 0.63–1.15); P = 0.30
Further findings
events
| Outcome | Microaxial flow pump | Standard care | HR (95% CI) | |
|---|---|---|---|---|
| All-cause death | 47 | 33 | 1.54 (0.99–2.41) | |
| 0.512Hazard ratio (log scale) |
Safety
Bleeding or vascular complications
- No material between-group difference
Original publication
Left Ventricular Unloading in High-Risk Percutaneous Coronary Intervention. N Engl J Med. Published 29 March 2026. doi:10.1056/nejmoa2515704
Summarised from the published abstract; every number is checked against it