Cardio-oncology & otherCohort study
Length of Hospital Stay for Endocarditis Before and After the Partial Oral Treatment of Endocarditis Trial
- Nationwide registry-based cohort study
- before-and-after comparison
- Danish nationwide registries
Authors' conclusion
Following the POET trial, we found a reduction in median LOS of 8 days with no change in mortality and an associated lower rate of relapse of bacteremia.
Study context
- Population
- Patients with first-time infective endocarditis (IE) caused by Streptococcus spp., Enterococcus faecalis, Staphylococcus aureus or coagulase-negative staphylococci, Denmark, 2012–2021
- Participants
- 3,008 vs 1,740
- Exposure
- After vs before POET trial publication
- Before POETn = 3,008reference
- After POETn = 1,740
- Outcome
- Median length of hospital stay
Main finding
Length of hospital stay
Median decrease
8 days
P < 0.0001
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
Mortality · 180 days
P = 0.41
LOS by microbiological etiology, age group and surgical treatment
- Similar reductions in LOS across microbiological etiologies and age groups
- Reduction in LOS most pronounced in nonsurgically treated patients
Safety
Bacteremia relapse · 180 days
P = 0.0002
Original publication
Length of Hospital Stay for Endocarditis Before and After the Partial Oral Treatment of Endocarditis Trial. J Am Coll Cardiol. Published 3 December 2024. doi:10.1016/j.jacc.2024.06.053
Summarised from the published abstract; every number is checked against it