Coronary disease & ACSRandomised controlled trial
Lessons learned from the feasibility phase of the REvascularization CHoices Among Under-Represented Groups Evaluation (RECHARGE) trial program
- pilot phase of 2 parallel randomized trials
- feasibility phase
Authors' conclusion
The lessons learned from the pilot phase of the REvascularization CHoices Among Under-Represented Groups Evaluation program can inform the design and implementation of future randomized trials seeking to enroll traditionally under-represented populations.
Study context
- Population
- Women, Black and Hispanic patients considered for percutaneous coronary intervention vs coronary artery bypass grafting, US and Canadian sitespatients randomized within 13 months of the pilot phase, full program enrolling 1200
- Participants
- 141 women
- Comparison
- percutaneous coronary intervention vs coronary artery bypass grafting
Primary result
As reported in the abstract
Reasons eligible patients were not randomized
- Physician and patient treatment preferences were the main reasons eligible patients were not randomized
Further findings
Site selection and activation · 2-year pilot phase
- US sites selected
- 91
- Canadian sites selected
- 17
- Sites activated
- 65
- Median activation time
- 10.8 months (Interquartile range [IQR] 9.1-13.6)
Enrollment · 13 months
- Pilot enrollment goal
- 60 participants
- Patients randomized
- 141
- Mean enrollment rate
- 0.27 patients/site/month
- prompting expansion to up to 150 sites for the full program
Original publication
Lessons learned from the feasibility phase of the REvascularization CHoices Among Under-Represented Groups Evaluation (RECHARGE) trial program. Am Heart J. Published 20 June 2026. doi:10.1016/j.ahj.2026.107515
Summarised from the published abstract; every number is checked against it