Heart failure & cardiomyopathiesRandomised controlled trial
Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial
- Randomised controlled trial
- multicentre
- open-label
Authors' conclusion
These findings question the benefit of fluid restriction in chronic heart failure.
Study context
- Population
- Outpatients with chronic HF67.3% male
- Participants
- 504 outpatients
- Comparison
- Liberal fluid intake vs fluid restriction
- Primary endpoint
- Health status by KCCQ Overall Summary Score (Kansas City Cardiomyopathy Questionnaire Overall Summary Score (KCCQ-OSS))
- Follow-up
- 3 months
Primary result
KCCQ-OSS
Mean difference
2.17
95% CI −0.06 to 4.39
P = 0.06
By group
Liberal fluid intake
74.0
Fluid restriction
72.2
Liberal fluid intake vs Fluid restriction
mean difference 2.17 (95% CI −0.06 to 4.39); P = 0.06
As reported in the abstract
Secondary outcomes
Thirst distress
- Thirst distress higher with fluid restriction
Safety
Safety events
- No differences between the two groups
Original publication
Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial. Nat Med. Published 30 March 2025. doi:10.1038/s41591-025-03628-4
Summarised from the published abstract; every number is checked against it