Arrhythmias & electrophysiology
Lead Integrity and Failure Evaluation in Left Bundle Branch Area Pacing: The LIFE-LBBAP Study
Authors' conclusion
LBBAP lead performance of LLLs and SDLs is high at midterm follow-up. SDLs exhibit higher rates of fracture compared to LLLs.
Study context
- Population
- Patients with successful left bundle branch area pacing (LBBAP)
- Participants
- 8,255 patients
- Exposure
- Lumenless leads vs stylet-driven leads for LBBAP
- LLLsn = 5,609reference
- Stylet-driven leads (SDLs)n = 2,646
- Outcome
- Lead integrity: overall lead survival, fracture rates and fracture locations
Methodological detailsmulticentre, 17 international centres, real-world
- Multicentre
- 17 international centres
- Real-world
Main finding
As reported in the abstract
Lead fracture
| Group | Value | Follow-up |
|---|---|---|
| LLLs | 0.04% | 19.5 (Q1-Q3: 9.7-33) months |
| SDLs | 0.4% | 10.3 (Q1-Q3: 2.9-19.7) months |
Value
LLLs0.04%
SDLs0.4%
Follow-up
LLLs19.5 (Q1-Q3: 9.7-33) months
SDLs10.3 (Q1-Q3: 2.9-19.7) months
- SDLs vs LLLs: P < 0.001 — fracture rate
- Overall lead survival rate
- 99.7%
- Overall lead fracture
- 12 of 8,255 (0.15%)
- Median follow-up
- 16.4 (Q1-Q3: 6.4-28.8) months
Observational data: associations, not effects.
Further findings
Timing and location of fractures
- SDL fractures occurred after implant at
- 13.9 (Q1-Q3: 6.1-17.7) months
- 2 LLL fractures occurred at
- 21 and 31.4 months
- Centres with SDL conductor fractures
- 7 of 17
- Centres with LLL conductor fractures
- 2 of 17
- Confirmed SDL fractures originated within the interelectrode lead segment; LLL fractures occurred proximal to the ring
Original publication
Lead Integrity and Failure Evaluation in Left Bundle Branch Area Pacing: The LIFE-LBBAP Study. JACC Clin Electrophysiol. Published 20 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →