Cardio-oncology & otherCohort study
Life’s Essential 8 and cardiovascular disease in women with a history of adverse pregnancy outcomes
- Prospective cohort study
- UK Biobank
Authors' conclusion
Among women with a history of APOs, better CVH as assessed using LE8 was associated with a significantly lower incidence of CVD, particularly CHD and AF. The excess risk associated with APOs appears to be attenuated among those with a high LE8 score.
Study context
- Population
- Women with a history of adverse pregnancy outcomes (APOs), UK Biobank2,263 with prior APOs
- Exposure
- Top vs bottom tertile of Life's Essential 8 score
- Outcome
- Incident total CVD
- Follow-up
- Median 13.5 years
Main finding
Total CVD, women with prior APOs
Hazard ratio
0.43
95% CI 0.29–0.65
T3 vs T1
HR 0.43 (95% CI 0.29–0.65)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CHD, women with prior APOs | 0.30 (0.17–0.55) | |
| AF, women with prior APOs | 0.47 (0.24–0.91) | |
| 0.10.31310Hazard ratio (log scale) |
Total cardiovascular disease (CVD), women without APOs
- Similar trend in women without APOs, HR
- 0.55 (0.53, 0.58) (95% CI)
Long-term CV risk, high LE8 score: prior APOs vs no prior APOs
- Similar long-term CV risk with high LE8 score, prior APOs vs no prior APOs
- 0.95 (0.63, 1.44)
Original publication
Life’s Essential 8 and cardiovascular disease in women with a history of adverse pregnancy outcomes. Eur J Prev Cardiol. Published 31 January 2025. doi:10.1093/eurjpc/zwaf021
Summarised from the published abstract; every number is checked against it