Cardiometabolic & kidneyCohort study
Life’s Essential 8 and heart failure among patients with chronic kidney disease: the Kailuan Cohort Study
- Prospective cohort study
Authors' conclusion
Our data showed a strong graded inverse association between the LE8-defined cardiovascular health and the risk of heart failure among patients with CKD.
Study context
- Population
- Patients with chronic kidney disease (CKD) free of CVD at recruitment, Kailuan Study (mean age 55.9 years)724 incident HF cases
- Participants
- 16,190 patients
- Exposure
- High or moderate vs low LE8 cardiovascular health
- High LE8n = 814
- Moderate LE8n = 13,180
- Low LE8n = 2,196reference
- Outcome
- Incident HF
- Follow-up
- Median 13.7 years
Main finding
As reported in the abstract
Each group vs low LE8Hazard ratio (95% CI)
Moderate LE8
0.58(0.48–0.71)
High LE8
0.32(0.19–0.54)
Observational data: associations, not effects.
Further findings
HF by age (≤65 vs >65 years) (subgroup)
- Association stronger in patients aged ≤65 years than in older patients
- P for interaction = 0.01
Original publication
Life’s Essential 8 and heart failure among patients with chronic kidney disease: the Kailuan Cohort Study. Eur J Prev Cardiol. Published 19 December 2023. doi:10.1093/eurjpc/zwad398
Summarised from the published abstract; every number is checked against it