Cardio-oncology & otherCohort study
Life’s Essential 8 and Incident Cardiovascular Disease in U.S. Women With Breast Cancer
- Prospective cohort study
Authors' conclusion
Higher LE8 scores were associated with a lower risk of incident CVD among women with BC in the United States.
Study context
- Population
- US women with breast cancer, Women's Health Initiative; median age 70.1 years at diagnosis
- Participants
- 7,165 women
- Exposure
- Moderate and high vs low cardiovascular health before breast cancer (BC) diagnosis
- Outcome
- Composite of incident CVD events (CHD [MI with coronary revascularization], CVD death, stroke)
- Follow-up
- Median 6 years
Main finding
As reported in the abstract
Incident CVD (490 composite events)
Each group vs low CVHHazard ratio (95% CI)
Moderate CVH
0.57(0.46–0.69)
High CVH
0.34(0.20–0.59)
Observational data: associations, not effects.
Further findings
LE8 score · before BC diagnosis
- Mean LE8 score
- 62.0 ± 12.2
Discrimination for composite cardiovascular disease (CVD) risk (LE8 with age)
- C-statistic
- 0.74
Original publication
Life’s Essential 8 and Incident Cardiovascular Disease in U.S. Women With Breast Cancer. JACC CardioOncol. Published 27 August 2024. doi:10.1016/j.jaccao.2024.07.008
Summarised from the published abstract; every number is checked against it