Valvular & structural heart diseaseCohort study
Lifestyle patterns, genetic susceptibility, and risk of valvular heart disease: a prospective cohort study based on the UK Biobank
- Prospective cohort study
Authors' conclusion
Our study reveals that adherence to a healthy lifestyle is significantly associated with a reduced risk of VHD especially AS, irrespective of genetic susceptibility.
Study context
- Population
- UK Biobank participants without valvular heart disease (VHD) at baseline; lifestyle = smoking, alcohol, diet, activity, sleep
- Participants
- 499,341 participants
- Exposure
- Intermediate or healthy lifestyle vs unhealthy lifestyle
- Outcome
- Incident VHD
- Follow-up
- Median 10.8 years
Main finding
As reported in the abstract
Each group vs unhealthy lifestyleHazard ratio (CI)
Intermediate lifestyle
0.81(0.76–0.86)
Healthy lifestyle
0.81(0.76–0.87)
- Risk of VHD and aortic stenosis (AS) decreased with healthier lifestyles
- P for trend < 0.001
- Association independent of genetic risk (interaction P, polygenic risk scores (PRSs)/family history of cardiovascular disease (CVD))
- 0.723/0.763
- Incident VHD cases
- 12 983 (2.46 per 1000 person-years)
Observational data: associations, not effects.
Further findings
Incident AS
- Incident AS cases
- 3527 (0.66 per 1000 person-years)
- Similar findings for AS, with a stronger negative association
Original publication
Lifestyle patterns, genetic susceptibility, and risk of valvular heart disease: a prospective cohort study based on the UK Biobank. Eur J Prev Cardiol. Published 1 June 2023. doi:10.1093/eurjpc/zwad177
Summarised from the published abstract; every number is checked against it