Heart failure & cardiomyopathiesCohort study
Lifetime cumulative activity burden is associated with symptomatic heart failure and arrhythmic risk in patients with arrhythmogenic right ventricular cardiomyopathy: a retrospective cohort study
- Retrospective cohort study
- single-centre
Authors' conclusion
This study demonstrates for the first time that cumulative physical activity as a continuous predictor variable is associated with symptomatic heart failure and arrhythmic risk in ARVC patients.
Study context
- Population
- Patients with arrhythmogenic right ventricular cardiomyopathy (ARVC), 93 with definite ARVC93 definite ARVC
- Participants
- 124 patients
- Exposure
- Cumulative physical activity burden and clinical endpoints
- Outcome
- Symptomatic HF, sustained VT and ICD interventions, by cumulative overall activity burden (Cox regression)
Main finding
As reported in the abstract
Cumulative overall activity burden, continuous model (HR per 100 METh/week)
Per 100 METh/weekHazard ratio (95% CI)P value
symptomatic HF
1.017(1.003–1.032)
P = 0.015sustained VT
1.021(1.006–1.037)
P = 0.007ICD interventions
1.017(1.000–1.034)
P = 0.048Per 100 METh/week, as printed
Observational data: associations, not effects.
Further findings
Reported activity
Metabolic equivalent of task-hours (METh)/week
- Median overall activity
- 202.3
- Sports-related activity
- 38.7
Sports-related vs non-sports-related activity as predictor
- Consistent association for sports-related activity; no significant association for non-sports-related activity
Original publication
Lifetime cumulative activity burden is associated with symptomatic heart failure and arrhythmic risk in patients with arrhythmogenic right ventricular cardiomyopathy: a retrospective cohort study. Europace. Published 21 September 2024. doi:10.1093/europace/euae236
Summarised from the published abstract; every number is checked against it