Cardiometabolic & kidneyCohort study
Linking Chronic Kidney Disease to Incident Heart Failure and Adverse Cardiac Remodeling Through the Plasma Proteome
- Prospective cohort study (proteomic analysis) with external validation and mendelian randomization
- longitudinal
- external validation in CRIC
- two-sample mendelian randomization
Authors' conclusion
This study identified 44 eGFR- and UACR-related plasma proteins that are associated with incident HF independently from demographics, risk factors, and kidney function.
Study context
- Population
- Participants of the ARIC (Atherosclerosis Risk In Communities) study; external validation in CRIC (Chronic Renal Insufficiency Cohort)
- Outcome
- Kidney function-related (eGFR or UACR) plasma proteins associated with incident HF
Main finding
As reported in the abstract
Plasma proteins associated with eGFR or UACR and incident HF
Proteins associated with estimated glomerular filtration rate (eGFR) or urine albumin-to-creatinine ratio (UACR) and incident heart failure (HF) at 2 separate ARIC visits (fully adjusted; of 4,697 measured)
44
Of these, validated externally in CRIC
29
Observational data: associations, not effects.
Further findings
HF subtype
- Most proteins associated with HFpEF, but not HFrEF
Cardiac remodeling
- A cluster within the 44 proteins associated with larger LV end-diastolic volume index and LV diastolic dysfunction
Mendelian randomization
- Golgi membrane protein 1 suggested causally associated with HF and eGFR
Original publication
Linking Chronic Kidney Disease to Incident Heart Failure and Adverse Cardiac Remodeling Through the Plasma Proteome. JACC Heart Fail. Published 26 June 2025. doi:10.1016/j.jchf.2025.102512
Summarised from the published abstract; every number is checked against it