Heart failure & cardiomyopathiesCohort study
Linking Coronary Microvascular Dysfunction to Cardiac Troponin Elevation in Transthyretin Amyloid Cardiomyopathy
- retrospective study
Authors' conclusion
In this selected invasive cohort with histologically confirmed ATTR-CM, higher hs-cTnT levels were independently associated with lower biopsy-derived MCD, impaired perfusion reserve, and elevated filling pressure, suggesting an integrated microvascular-haemodynamic substrate of persistent myocardial injury.
Study context
- Population
- Hospitalized patients with left ventricular hypertrophy (LVH) who underwent invasive physiological assessment of the left anterior descending artery, right heart catheterization, and endomyocardial biopsy as part of the etiological evaluationhospitalized patients with LVH · ATTR-CM 51 · reference group 20
- Participants
- 71 patients
- Exposure
- within-ATTR-CM associations of high-sensitivity cardiac troponin T (hs-cTnT) with coronary flow reserve (CFR), index of microcirculatory resistance (IMR), myocardial capillary density (MCD), sampled transthyretin deposition, haemodynamic and imaging parameters
- ATTR-CMn = 51
- contextual reference groupn = 20
Main finding
As reported in the abstract
Independent associations of higher hs-cTnT levels (within the ATTR-CM cohort)
higher pulmonary artery wedge pressure, standardized β
0.46, p = 0.0001
lower CFR, β
−0.26, p = 0.027
lower MCD, β
−0.24, p = 0.037
Observational data: associations, not effects.
Original publication
Linking Coronary Microvascular Dysfunction to Cardiac Troponin Elevation in Transthyretin Amyloid Cardiomyopathy. ESC Heart Fail. Published 15 September 2026. doi:10.1093/eschf/xvag238
Summarised from the published abstract; every number is checked against it