Lipid-Lowering Therapy Preferences in the LISTEN-LDL-US Study: A Survey of U.S. Patient Treatment Experiences and Needs
Authors' conclusion
Mode of administration is a key driver of LLT preferences. Incorporating patient preferences into shared decision-making may improve adherence and implementation of guideline-directed therapy.
Study context
- Population
- Adults ≥40 years with elevated low-density lipoprotein cholesterol (LDL-C) and a recommendation for lipid-lowering therapy (LLT)
- Participants
- 508 adults
- Exposure
- Preferences across 7 LLT attributes: LDL-C reduction, stroke risk, heart attack risk, revascularization risk, new-onset diabetes, musculoskeletal pain, and regimen/mode of administration
Methodological detailsdiscrete choice experiment, hierarchical Bayesian modeling
- Discrete choice experiment
- Hierarchical Bayesian modeling
Main finding
As reported in the abstract
Participant characteristics
Mean age (years)
62.8 ± 11.4
Prior atherosclerotic cardiovascular disease (ASCVD)
49.0%
Female
55.3%
Current or former smokers
43.9%
Observational data: associations, not effects.
Further findings
Prioritization of treatment features
- Participants prioritized immediate and tangible treatment features over long-term benefits
Relative importance of mode of administration
- Mode of administration was the most influential attribute (relative importance)
- 25.9
Preference weights for regimen
- Once-daily oral pill (most preferred)
- Preference weights (PW) = 1.75
- Daily pill plus a second oral pill before breakfast
- PW = 0.17
- Regimens including biweekly injections (least preferred)
- PW = −1.13
Perceived ASCVD risk and preferences
- Higher perceived ASCVD risk was associated with greater emphasis on cardiovascular risk reduction and less emphasis on regimen
Original publication
Lipid-Lowering Therapy Preferences in the LISTEN-LDL-US Study: A Survey of U.S. Patient Treatment Experiences and Needs. JACC Adv. Published 19 August 2026. doi:10.
Summarised from the published abstract; every number is checked against it