Valvular & structural heart diseaseMeta-analysis
Lipoprotein(a) and Calcific Aortic Valve Stenosis Progression
- Pooled analysis of 5 longitudinal cohort studies
- multicentre
Authors' conclusion
In this study, higher plasma lipoprotein(a) concentrations were associated with faster rates of hemodynamic progression in patients with aortic stenosis.
Study context
- Population
- Patients with AS from 5 longitudinal clinical studies in Canada and the UK, March 2001 to March 2023710 analysed
- Participants
- 757 patients
- Comparison
- Top vs bottom lipoprotein tertile
- Outcome
- Hemodynamic AS progression on echocardiography: annualized change in peak aortic jet velocity, mean transvalvular gradient and aortic valve area
Pooled result
As reported in the abstract
Annualized hemodynamic AS progression on echocardiography
Estimate
- peak aortic jet velocity: 41% faster progression
- 1.41 (95% CI 1.13–1.75)
- mean transvalvular gradient: 57% faster progression
- 1.57 (95% CI 1.18–2.10)
- Progression of aortic valve area comparable between groups
- estimate 1.23 (95% CI 0.71-2.12)
Further pooled results
Lipoprotein(a) as a continuous variable
- Similar results
Original publication
Lipoprotein(a) and Calcific Aortic Valve Stenosis Progression. JAMA Cardiol. Published 1 September 2024. doi:10.1001/jamacardio.2024.1882
Summarised from the published abstract; every number is checked against it