Prevention & lipidsMeta-analysis
Lipoprotein (a) and incident coronary heart disease in the community: impact of traditional cardiovascular risk factors
- Pooled analysis of prospective population-based cohorts
- 8 European cohorts
- Fine and Gray competing risk-adjusted models
Authors' conclusion
Among CHD-free subjects, high Lp(a) was related to adverse outcome even in individuals with no or only one CVRF at baseline, thereby generating substantial challenges in mitigating Lp(a)-associated CHD risk in very low risk populations.
Study context
- Population
- Coronary heart disease (CHD)-free individuals from the general population, 8 European prospective cohorts
- Participants
- 66,495 individuals · 8 cohorts
- Comparison
- Lp ≥90th pctl. vs <90th pctl., by CV risk factors (CVRF) burden
- 0/1 CVRFn = 41,770
- ≥2 CVRFsn = 24,725
- Outcome
- Incident CHD events by Lp(a) mass (≥90th vs <90th pctl.; cut-off 43.2 mg/dL)
- Follow-up
- Median 9.7 years
Pooled result
As reported in the abstract
Incident CHD, elevated Lp(a) (≥90th pctl.), by CVRF subgroup
Subdistribution hazard ratio (95% CI)
0/1 CVRF
1.38(1.12–1.71)
≥2 CVRFs
1.27(1.10–1.46)
- Incident CHD events
- 3,467
Original publication
Lipoprotein (a) and incident coronary heart disease in the community: impact of traditional cardiovascular risk factors. Eur J Prev Cardiol. Published 12 June 2025. doi:10.1093/eurjpc/zwaf340
Summarised from the published abstract; every number is checked against it