Pulmonary vascular disease & thromboembolismCohort study
Lipoprotein(a) and incident venous thromboembolism in pre- and postmenopausal women, and in men
- Prospective cohort study
- UK Biobank
- multivariable-adjusted Cox models
Authors' conclusion
Elevated Lp(a) was associated with VTE in premenopausal women and in postmenopausal MHT users, suggesting that hormonal context may influence Lp(a)-associated thrombotic risk.
Study context
- Population
- UK Biobank participants with baseline Lp(a), without prior venous thromboembolism (VTE) or cancer and not using anticoagulants; premenopausal women, postmenopausal women and men55,302 premenopausal women · 129,045 postmenopausal women · 189,013 men
- Exposure
- Lp ≥125 nmol/L vs lower Lp
- Outcome
- Incident VTE
- Follow-up
- Median 13.6 (IQR 12.9-14.4) years
Main finding
As reported in the abstract
Incident VTE, by sex and menopausal status
Lp(a) ≥125 nmol/LAdjusted hazard ratio (95% CI)P value
premenopausal women
1.32(1.04–1.66)
P = 0.02postmenopausal women; Pinteraction = .03
1.03(0.94–1.13)
P = 0.47men
1.00(0.92–1.08)
P = 0.94- VTE events, all participants
- 8186
- Cumulative VTE incidence
- 2.2%
Observational data: associations, not effects.
Further findings
Incident VTE, postmenopausal menopausal hormone therapy (MHT) users (subgroup)
| Comparison | aHR (95% CI) | P value | |
|---|---|---|---|
| Lp(a) ≥125 nmol/L | 1.48 (1.03–2.12) | P = 0.03 | |
| 0.512Adjusted hazard ratio (log scale) |
| Outcome | Values | Estimate | P value |
|---|---|---|---|
| Proportion with Lp(a) ≥125 nmol/L · baseline | Premenopausal women 14.0% · Postmenopausal women 19.0% · Men 15.0% |
- Incident VTE, postmenopausal MHT users (subgroup): Pinteraction = .04
Incident VTE, premenopausal women by oral contraceptive (OCP) use (subgroup)
- OCP use did not modify the Lp(a)-VTE association
- P for interaction = 0.61
Original publication
Lipoprotein(a) and incident venous thromboembolism in pre- and postmenopausal women, and in men. Eur Heart J. Published 28 March 2026. doi:10.1093/eurheartj/ehag252
Summarised from the published abstract; every number is checked against it