Coronary disease & ACSCohort study
Lipoprotein(a) and long-term revascularization burden: a recurrent-event analysis of the UK Biobank
- recurrent-event analysis of the UK Biobank
- primary prevention cohort
Authors' conclusion
In this large primary prevention cohort, elevated Lp(a) was independently associated with a higher long-term revascularization burden across multiple vascular territories. The association was robust for coronary, supportive for peripheral, and inconclusive for carotid revascularization owing to limited statistical power. These findings, derived from recurrent-event methodology, provide a more complete quantification of Lp(a)-associated cardiovascular procedural risk than time-to-first-event analyses alone.
Study context
- Population
- UK Biobank participants of European ancestry free of ASCVD at baselinemedian follow-up 14.1 years
- Participants
- 237,729 participants
- Exposure
- Lp ≥ 105 vs. <105 nmol/L
- Outcome
- total number of coronary, peripheral, and carotid revascularization procedures per person
- Follow-up
- Median of 14.1 years
Main finding
As reported in the abstract
Per person, as printed
- revascularization procedures occurred
- 10 731
Observational data: associations, not effects.
Further findings
Revascularization by procedure order
| Comparison | HR (CI) | |
|---|---|---|
| Lp(a) ≥ 105 nmol/L · first procedure | 1.48 (1.40–1.56) | |
| Lp(a) ≥ 105 nmol/L · second procedure | 1.28 (1.09–1.50) | |
| Lp(a) ≥ 105 nmol/L · third procedure; non-significant | 1.23 (0.94–1.62) | |
| 0.512Hazard ratio (log scale) |
Revascularization by procedure order
- Findings were consistent across coronary and peripheral territories
Original publication
Summarised from the published abstract; every number is checked against it