Coronary disease & ACSMeta-analysis
Lipoprotein(a), atherosclerotic plaque burden, and long-term cardiovascular outcomes in patients with coronary artery disease
- Pooled analysis of the ATHEROREMO and IBIS-3 observational studies
- Intravascular ultrasound (IVUS) and near-infrared spectroscopy of a non-culprit segment
Authors' conclusion
Among patients with established ASCVD, Lp(a) was associated with plaque burden, supporting evidence that relates Lp(a) to atherosclerotic disease. However, Lp(a) was not associated with long-term mortality or cardiac adverse events in these patients.
Study context
- Population
- Patients undergoing coronary angiography for stable angina or ACS
- Participants
- 798 patients
- Comparison
- Lp >125 nmol/L vs lower Lp
Pooled result
As reported in the abstract
IVUS plaque burden; long-term clinical outcomes
Lp(a) vs Lp(a) ≤125 nmol/LHazard ratio (95% CI)P value
5-year MACE
1.06(0.70–1.60)
P = 0.7810-year all-cause mortality
0.63(0.38–1.06)
P = 0.78Original publication
Lipoprotein(a), atherosclerotic plaque burden, and long-term cardiovascular outcomes in patients with coronary artery disease. Eur J Prev Cardiol. Published 12 March 2026. doi:10.1093/eurjpc/zwag138
Summarised from the published abstract; every number is checked against it