Prevention & lipidsSecondary analysis
Lipoprotein(a), Cholesterol, Triglyceride Levels, and Vulnerable Coronary Plaques
- Secondary analysis of the PROSPECT II natural history study
- 3-vessel NIRS-IVUS imaging
- multivariable analysis
Authors' conclusion
In PROSPECT II, elevated TC, LDL-C, and non-HDL-C were strongly associated with pancoronary atherosclerosis and lipid deposition, whereas elevated Lp(a) was strongly associated with the presence of focal vulnerable plaques.
Study context
- Population
- Patients with recent myocardial infarction (MI) after treatment of all flow-limiting lesions
- Participants
- 865 patients
- Comparison
- Lipoprotein levels (total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-HDL-C, HDL-C, Lp(a), TG) vs pancoronary plaque and focal vulnerable plaque
- Primary endpoint
- Pancoronary plaque volume, pancoronary lipid core burden index (LCBI) and presence of focal vulnerable plaques (plaque burden ≥70% and maximum LCBI over any 4-mm segment ≥324.7)
Primary result
As reported in the abstract
TC, LDL-C and non-HDL-C (not Lp(a)) associated with pancoronary plaque volume and pancoronary lipid core burden index (LCBI)
P < 0.01 for all
Lp(a) (not TC, LDL-C or non-HDL-C) associated with presence of focal vulnerable plaques
P = 0.01
Original publication
Lipoprotein(a), Cholesterol, Triglyceride Levels, and Vulnerable Coronary Plaques. J Am Coll Cardiol. Published 3 June 2025. doi:10.1016/j.jacc.2025.04.013
Summarised from the published abstract; every number is checked against it