Lipoprotein(a) Levels in Disaggregated Racial and Ethnic Subgroups Across Atherosclerotic Cardiovascular Disease Risk Levels
Authors' conclusion
Of those tested, Lp(a) levels were frequently elevated and differed significantly across disaggregated race and ethnicity groups. The prevalence of elevated Lp(a) increased with increasing ASCVD risk, with significant variation by race and ethnicity.
Study context
- Population
- Adults (≥18 years) with ≥2 primary care visits and complete race and ethnicity data who underwent Lp(a) testing, large California health care system, 2010–20210.9% underwent Lp(a) testing
- Participants
- 13,689 adults
- Exposure
- Elevated Lp by disaggregated race, ethnicity and atherosclerotic cardiovascular disease (ASCVD) risk
- Outcome
- Elevated Lp(a) (≥50 mg/dL)
Main finding
As reported in the abstract
Each group vs NH WhiteOdds ratio (95% CI)
Hispanicadjusted; lower odds
0.76(0.66–0.88)
Asianadjusted; lower odds
0.88(0.81–0.96)
Blackadjusted; higher odds
2.46(1.97–3.07)
Observational data: associations, not effects.
Further findings
| Outcome | NH White | NH-Black | Hispanic | NH-Asian | |
|---|---|---|---|---|---|
| ASCVD risk of those tested, by race | |||||
| Established ASCVD | Not reported in the abstract | 27.2% | Not reported in the abstract | Not reported in the abstract | NH White, Hispanic, NH-Asian: not reported in the abstract |
- ASCVD risk of those tested, by race: Asian Indian 73.6% · <5% 10-year risk 73.6%
Elevated Lp(a) across ASCVD risk spectrum
- Prevalence of Lp(a) ≥50 mg/dL increased across the ASCVD risk spectrum
Original publication
Lipoprotein(a) Levels in Disaggregated Racial and Ethnic Subgroups Across Atherosclerotic Cardiovascular Disease Risk Levels. JACC Adv. Published 2 May 2024. doi:10.
Summarised from the published abstract; every number is checked against it