Cohort study
Lipoprotein(a), Oxidized Phospholipids, and Coronary Artery Disease Severity and Outcomes
- Prospective cohort study
Authors' conclusion
In patients undergoing coronary angiography, Lp(a) and OxPL-apoB are associated with multivessel CAD. Lp(a), OxPL-apoB, and OxPL-apo(a) are associated with incident cardiovascular events.
Study context
- Population
- Patients referred for coronary angiography (CASABLANCA study)
- Participants
- 1,098 patients
- Exposure
- Lp, OxPL-apoB and OxPL-apo levels
- Outcome
- Multivessel coronary artery disease (CAD) (angiographic) and MACE (coronary revascularization, nonfatal MI, nonfatal stroke, CV death)
Main finding
As reported in the abstract
Multivessel CAD and MACE, per doubling of biomarker
Estimate (95% CI)P value
Lp(a) per doublingmultivessel CAD
OR 1.10(1.03–1.18)
P = 0.006OxPL-apoB per doublingmultivessel CAD
OR 1.18(1.03–1.34)
P = 0.01OxPL-apo(a) per doublingmultivessel CAD
OR 1.07(0.99–1.16)
P = 0.07Lp(a) per doublingMACE
HR 1.08(1.03–1.14)
P = 0.001OxPL-apoB per doublingMACE
HR 1.15(1.05–1.26)
P = 0.004OxPL-apo(a) per doublingMACE
HR 1.07(1.01–1.14)
P = 0.02Per doubling, as printed
Observational data: associations, not effects.
Further findings
Lp(a) level (cohort)
- Median Lp(a), nmol/L (IQR 11.39-89.49)
- 26.45
Correlation of Lp(a), OxPL-apoB and OxPL-apo(a)
- Highly correlated, Spearman R for all pairwise combinations
- ≥0.91
Original publication
Lipoprotein(a), Oxidized Phospholipids, and Coronary Artery Disease Severity and Outcomes. J Am Coll Cardiol. Published 9 May 2023. doi:10.1016/j.jacc.2023.02.050
Summarised from the published abstract; every number is checked against it