Location-specific prognostic significance of plaque burden, stenosis, and plaque morphology in coronary artery disease
Authors' conclusion
Proximal PAV was the strongest predictor of MACE when adjusted for cardiovascular risk factors and plaque at other locations. However, when the presence of plaque was only adjusted for cardiovascular risk factors, proximal, mid, and distal plaque localization showed a similar predictive ability for MACE.
Study context
- Population
- Patients without documented cardiac history undergoing coronary CT angiography for suspected CAD267 events (9.5%)
- Participants
- 2,819 patients
- Exposure
- Proximal vs mid vs distal coronary plaque location
- Outcome
- MACE:
- Death
- Non-fatal MI
- Follow-up
- Median 6.9 years
Main finding
As reported in the abstract
Prediction of MACE (adjusted for CV risk factors only)
| Group | AUC |
|---|---|
| Proximal percentage atheroma volume (PAV) | 0.73 (95% CI 0.69-0.76) |
| Mid PAV | 0.72 (95% CI 0.68-0.76) |
| Distal PAV | 0.72 (95% CI 0.68-0.76) |
AUC
Proximal percentage atheroma volume (PAV)0.73 (95% CI 0.69-0.76)
Mid PAV0.72 (95% CI 0.68-0.76)
Distal PAV0.72 (95% CI 0.68-0.76)
Observational data: associations, not effects.
Further findings
Correlation of proximal PAV with mid and distal PAV
- Proximal vs mid PAV correlation
- R = 0.76
- Proximal vs distal PAV correlation
- R = 0.74
- P < 0.01 for both
Proximal low-attenuation plaque
- Borderline additional prognostic value
Original publication
Location-specific prognostic significance of plaque burden, stenosis, and plaque morphology in coronary artery disease. Eur Heart J Cardiovasc Imaging. Published 20 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →