Prevention & lipidsCross-sectional study
Long-term ambient air pollution exposure and coronary calcium score in men: insights from the DANCAVAS study
- Cross-sectional study
- cohort from the DANCAVAS screening trials
Authors' conclusion
Exposure to PM2.5 was modestly associated with the presence of CAC, particularly when combining residential and workplace exposures. No consistent associations were observed with NO2 or advanced stages of calcification.
Study context
- Population
- Men aged 60–75 years from the Danish Cardiovascular Screening Trials (DANCAVAS)
- Participants
- 12,301 men
- Exposure
- Long-term PM2.5 and NO2 exposure and coronary calcium score
- Outcome
- CCS ≥ 100
Main finding
As reported in the abstract
- Binary logistic regression: no significant associations
Observational data: associations, not effects.
Secondary outcomes
| Outcome | adjusted OR (95% CI) | |
|---|---|---|
| CAC presence (CCS = 0 vs CCS ≥ 1), ordinal-scaled CCS · generalized ordinal logistic regression | 1.11 (1.04–1.18) | |
| 0.512Adjusted odds ratio (log scale) |
Coronary artery calcification (CAC) presence (coronary calcium score (CCS) = 0 vs CCS ≥ 1), ordinal-scaled CCS
- No associations for higher CAC categories
- NO2: non-significant findings
- Addition of workplace exposure: only moderate changes in effect estimates
Exposure and CCS distribution
- Median PM2.5 exposure, µg/m3 (IQR 13.2-14.1)
- 13.7
- Median NO2 exposure, µg/m3 (IQR 14.7-18.4)
- 16.3
- Median CCS (IQR 8-410)
- 99
Original publication
Long-term ambient air pollution exposure and coronary calcium score in men: insights from the DANCAVAS study. Eur J Prev Cardiol. Published 27 October 2025. doi:10.1093/eurjpc/zwaf688
Summarised from the published abstract; every number is checked against it