Coronary disease & ACSCohort study
Long-term cardiovascular outcomes in patients hospitalised with acute coronary syndrome subtypes in Western Australia, 2002–2019
- Linked hospitalisation and mortality data cohort
- Cox proportional hazards modelling after adjustment for potential confounders
Authors' conclusion
Long-term risk of MACE and all-cause death remains high and unchanged among 30-day survivors of all ACS subtypes in the recent era. Long-term surveillance and optimal secondary prevention are important in survivors of all ACS subtypes.
Study context
- Population
- 30-day survivors of index STEMI, non-STEMI (NSTEMI) and unstable angina (UA) hospitalisation in Western Australia between 2002 and 2019patients with acute coronary syndrome (ACS), 65% males
- Participants
- 73,321 survivors
- Exposure
- NSTEMI vs STEMI and UA; STEMI or NSTEMI versus UA
Main finding
As reported in the abstract
Cohort composition by ACS subtype
| Group | Value | mean age |
|---|---|---|
| STEMI | 22.3% | 63.2 |
| NSTEMI | 43.2% | 68.8 |
| UA | 34.6% | 66.4 |
Observational data: associations, not effects.
Further findings
Cumulative MACE (non-fatal MI, stroke, heart failure hospitalisation or cardiovascular death) · 5-year
All-cause mortality · 5-year
- Cumulative major adverse cardiovascular events (MACE) (non-fatal MI, stroke, heart failure hospitalisation or cardiovascular death): log-rank p<0.001
- All-cause mortality: log-rank p<0.001
Temporal trend in multivariable-adjusted risk of outcomes
- No temporal improvement for all ACS subtypes throughout the study period
Adjusted HRs for MACE and all-cause death, STEMI or NSTEMI versus UA, in males and females
- Adjusted HRs 1.5-fold or higher
- 1.5-fold or higher
Baseline characteristics
- Patients with NSTEMI and UA compared with STEMI were more likely to be female with additional comorbidities
Original publication
Long-term cardiovascular outcomes in patients hospitalised with acute coronary syndrome subtypes in Western Australia, 2002–2019. Heart. Published 25 June 2026. doi:10.1136/heartjnl-2026-327843
Summarised from the published abstract; every number is checked against it