Heart failure & cardiomyopathiesCohort study
Long-Term Exposure to Fine Particulate Matter Constituents, Genetic Susceptibility, and Incident Heart Failure Among 411 807 Adults
- Prospective cohort study
Authors' conclusion
Long-term exposure to PM2.5 constituents may elevate HF risk, and EC was the major contributor. Additive effects of PM2.5 constituents and PRS on HF risk were revealed.
Study context
- Population
- Adults in the UK Biobank7,554 developed heart failure (HF)
- Participants
- 411,807 adults
- Exposure
- PM2.5 and its constituents, with genetic susceptibility
- Outcome
- Incident HF
- Follow-up
- Median 12.05 years
Main finding
As reported in the abstract
Incident HF, adjusted HR per IQR increase
Adjusted hazard ratio (CI)
PM2.5
1.50(1.46–1.54)
EC
1.31(1.27–1.34)
OM
1.12(1.09–1.15)
NH4 +
1.42(1.41–1.44)
NO3 -
1.26(1.23–1.29)
SO4 2-
1.25(1.24–1.26)
Per IQR increase, as printed
Observational data: associations, not effects.
Further findings
Main contributor among PM2.5 constituents (quantile-based g-computation)
- Elemental carbon (EC) played the most important role, followed by NH4 + and SO4 2-
- 43%
Additive interaction of PM2.5, NH4 +, NO3 -, SO4 2- with polygenic risk score (PRS)
- Synergistic additive interactions accounted for this share of HF events in individuals exposed to both
- 9-16%
Original publication
Long-Term Exposure to Fine Particulate Matter Constituents, Genetic Susceptibility, and Incident Heart Failure Among 411 807 Adults. Eur J Heart Fail. Published 22 October 2024. doi:10.1002/ejhf.3486
Summarised from the published abstract; every number is checked against it