Coronary disease & ACSCohort study
Long-Term Exposure to PM2.5 Constituents and Coronary Heart Disease Risk in China
- Prospective cohort study
- nationwide
Authors' conclusion
Long-term exposure to specific PM2.5 constituents was associated with increased risks of coronary heart disease and AMI
Study context
- Population
- Adults free of CVD at baseline in the China-PAR Project, China, followed 2003–2019
- Participants
- 101,906 adults · 1,230,732 person-years
- Exposure
- Long-term exposure to PM2.5 constituents, per IQR increase
- Outcome
- CHD incidence (also CHD mortality and AMI incidence and mortality)
- Follow-up
- Median 11.08 years
Main finding
As reported in the abstract
CHD incidence, per IQR increase in exposure
Hazard ratio (95% CI)
EC
1.10(1.01–1.19)
OC
1.60(1.31–1.95)
Nitrate
1.43(1.06–1.95)
Sulfate
0.93(0.82–1.06)
Per IQR increase, as printed
- Incident CHD cases
- 3,500
Observational data: associations, not effects.
Further findings
CHD mortality and acute myocardial infarction (AMI) outcomes
- Incident AMI events
- 1,771
- CHD deaths
- 1,321
- AMI deaths
- 808
- Similar positive associations for elemental carbon (EC), organic carbon (OC) and nitrate; sulfate weaker and less consistent across outcomes
Concentration-response curves
- Overall increasing CHD risk for OC, EC and nitrate, with plateau or slight attenuation at higher EC and OC exposure; sulfate nonlinear without sustained increase in risk
Original publication
Long-Term Exposure to PM2.5 Constituents and Coronary Heart Disease Risk in China. J Am Coll Cardiol. Published 15 July 2026. doi:10.1016/j.jacc.2026.05.030
Summarised from the published abstract; every number is checked against it