Acute cardiac care & resuscitation

Long-term functional outcome and quality of life 5–8 years after out of hospital cardiac arrest

ResuscitationPublished Secondary analysis of the TTH48 randomised trial

Authors' conclusion

Long-term OHCA survivors had acceptable outcomes, though self-reported sleep and fatigue problems and relatives-reported cognitive decline were prevalent. Higher age and longer ROSC delay were risk factors of poorer outcome, primarily driven by mortality. Female sex was a risk factor of worse self-reported outcomes.

Study context

Population
OHCA survivors from participating TTH48 sites, contacted 5–8 years post OHCA, and their relatives161 (58%) alive
Participants
279 survivors
Primary endpoint
Functional outcomes and quality of life
Follow-up
5-8 years post OHCA
Methodological detailsmulticentre, long-term follow-up sub-study
  • Multicentre
  • Long-term follow-up sub-study

Primary result

As reported in the abstract

Long-term outcomes of participating survivors
Favourable outcome (CPC 1-2)
97.8%
Anxiety
5.5%
Depression
2.7%
PTSD
4.5%
Sleep problems
24.5%
Fatigue
45.5%
Working full- or part-time
40.7%

Further findings

Relatives' outcomes

Anxiety
7.0%
Depression
1.2%
PTSD
3.5%
Relatives reporting patient cognitive decline post OHCA
52.3%

Factors associated with long-term outcomes

ROSC delay, higher age and female sex negatively associated with several long-term outcomes
Treatment allocation not associated with better outcomes

Original publication

Long-term functional outcome and quality of life 5–8 years after out of hospital cardiac arrest. Resuscitation. Published 9 June 2025. doi:10.1016/j.resuscitation.2025.110672

Summarised from the published abstract; every number is checked against it

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