Valvular & structural heart diseaseCohort study
Long-Term Impact of Mild Paravalvular Regurgitation After Transcatheter Aortic Valve Replacement
- Registry-based cohort study
Authors' conclusion
Mild PVR after TAVR is associated with a significantly increased risk for BVF and all-cause mortality
Study context
- Population
- Patients after transcatheter aortic valve replacement (TAVR) with no, trace or mild paravalvular regurgitation (PVR) at discharge (OCEAN-TAVI registry)median follow-up 4.7 years
- Participants
- 5,068 patients
- Exposure
- Mild PVR vs no or trace PVR after TAVR
- Mild PVRn = 1,601
- Outcome
- All-cause mortality and bioprosthetic valve failure (BVF, VARC-3 criteria)
- Follow-up
- Up to 9 years
Main finding
As reported in the abstract
All-cause mortality and BVF
Mild PVR
75.9% (95% CI: 71.3%-80.2%)
All-cause mortality · bioprosthetic valve failure (BVF) 20.7% (95% CI: 12.8%-32.5%)
No or trace PVR
72.2% (95% CI: 68.1%-76.3%)
All-cause mortality · BVF 17.3% (95% CI: 11.0%-26.6%)
Mild PVR vs No or trace PVREstimate (95% CI)P value
BVF, Fine-Gray; cumulative incidence P = 0.029
sHR 1.48(1.07–2.04)
P = 0.018all-cause mortality, Cox; log-rank P = 0.014
HR 1.11(1.02–1.21)
P = 0.014Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| BVF by subgroup — Mild PVR vs No or trace PVR · balloon-expandable valves | sHR 1.46 (95% CI 1.02–2.08) | P = 0.038 | |
| BVF by subgroup — Mild PVR vs No or trace PVR · nontransfemoral TAVR | sHR 5.58 (95% CI 1.57–19.9) | P = 0.0086 | |
| BVF by subgroup — Mild PVR vs No or trace PVR · eGFR < 30 mL/min/1.73 m² | sHR 3.86 (95% CI 1.30–11.5) | P = 0.015 | |
| Progression to moderate or greater PVR | HR 3.74 (95% CI 2.84–4.92) | P < 0.001 | |
| 0.050.21520Ratio (log scale) |
Original publication
Long-Term Impact of Mild Paravalvular Regurgitation After Transcatheter Aortic Valve Replacement. JACC Cardiovasc Interv. Published 14 November 2025. doi:10.1016/j.jcin.2025.09.004
Summarised from the published abstract; every number is checked against it