Arrhythmias & electrophysiology
Long-term incidence of implantable cardioverter-defibrillator therapy in patients with hypertrophic cardiomyopathy: analysis of appropriate and inappropriate interventions
Authors' conclusion
One-third of patients with HCM treated with an ICD experienced appropriate ICD therapy. The HCM-Risk SCD score adequately distinguished between low-risk and high-risk patients among those who underwent ICD implantation. Further improvements of risk-tools are needed to identify a larger proportion of the two-thirds of patients who did not benefit from ICD implantation after 10 years of observation.
Study context
- Population
- Patients with hypertrophic cardiomyopathy (HCM) treated with an ICD for primary or secondary prevention between 1995 and 2022 in Eastern Denmark66% male, primary prevention (78%), secondary prevention (22%)
- Participants
- 208 patients
- Exposure
- ICD therapy by indication (secondary vs primary prevention) and by European Society of Cardiology HCM Risk-SCD score
- Outcome
- Appropriate ICD therapy (antitachycardia pacing and/or shock)
- Follow-up
- median 10-year follow-up
Main finding
As reported in the abstract
Patients who received appropriate ICD therapy
66 patients
32%
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| Appropriate therapy by ICD indicationSecondary prevention vs primary prevention | secondary prevention 47% · primary prevention 28% | P = 0.02 |
| Cumulative incidence of appropriate shock therapy · 5-year | high HCM Risk-SCD score 17% · intermediate-risk score 16% · low-risk score 6% |
- Cumulative incidence of appropriate shock therapy — A high-risk score was associated with higher cumulative incidence of appropriate shock therapy
- p=0.012
- Appropriate therapy by ICD indication: almost twice as likely to receive appropriate therapy with secondary prevention
Safety
Inappropriate ICD therapy · median 10-year follow-up
- Patients who received inappropriate therapy
- 20 (10%)
Original publication
Long-term incidence of implantable cardioverter-defibrillator therapy in patients with hypertrophic cardiomyopathy: analysis of appropriate and inappropriate interventions. Heart. Published 19 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →