Cardiometabolic & kidneyCohort study
Long-term major adverse cardiovascular and cerebrovascular event risk in adult-onset type 1 versus type 2 diabetes: a propensity-matched cohort study
- Retrospective cohort study
- propensity-score matched
- multicentre
Authors' conclusion
Compared with a propensity-matched phenotypically selected T2DM comparator cohort, T1DM was associated with lower 10-year MACCE and modestly lower all-cause mortality risk, suggesting lower relative cardiovascular event burden in newly diagnosed adults.
Study context
- Population
- Adults diagnosed with T1DM or T2DM 2005–2015, US multicentre database (TriNetX), followed through 2025matched n = 33,364
- Participants
- 36,599 vs 1,740,748
- Exposure
- Adult-onset T1DM vs T2DM
- T1DMn = 36,599
- T2DMn = 1,740,748reference
- Outcome
- MACCE:
- Stroke
- Hemorrhage
- Cardiac arrest
- HF
- MI
- Peripheral vascular events
- Revascularization procedures
- Follow-up
- 10 years
Main finding
10-year MACCE
Relative risk
0.48
P < 0.001
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
All-cause mortality · 10 years
RR 0.92 · P = 0.003
All-cause mortality, patients prescribed antihyperglycemics (stratum) · 10 years
RR 1.07 · P = 0.45
- 10-year major adverse cardiovascular and cerebrovascular (MACCE) incidence, unmatched T1DM cohort · 10 years
- 5.2%
- All-cause mortality: matched cohort (n = 33 364)
All-cause mortality, patients prescribed antihyperglycemics (stratum) · 10 years
- Lower MACCE and mortality in T1DM held upon stratification, except mortality, similar with antihyperglycemics
Original publication
Long-term major adverse cardiovascular and cerebrovascular event risk in adult-onset type 1 versus type 2 diabetes: a propensity-matched cohort study. Eur J Prev Cardiol. Published 10 July 2026. doi:10.1093/eurjpc/zwag360
Summarised from the published abstract; every number is checked against it