Acute cardiac care & resuscitationCohort study
Long-Term Neurological Outcome of Out-of-Hospital Cardiac Arrest Survivors and Associated Factors: Results of the DESAC Study, a French Multicentric Prospective Cohort
- multicentric prospective cohort
- 33 intensive care units in Paris and the suburbs (France)
- consecutive patients
Authors' conclusion
This multicentric prospective study indicates that 86% of out-of-hospital cardiac arrest survivors had a favorable neurological outcome at 24 months. Pre-event and intraevent factors (including previous practice of sport and shockable rhythm), but not in-hospital management (therapeutic hypothermia or acute coronary interventions), were associated with a favorable outcome.
Study context
- Population
- Consecutive nontraumatic out-of-hospital cardiac arrest patients aged over 18 years discharged alive from intensive care units, July 2015 to October 2018survivors, 525 followed up for 24 months
- Participants
- 593 patients
Main finding
As reported in the abstract
Favorable neurological outcome (CPC category of 1 or 2) · 24 months
Favorable neurological outcome
449 of 525 (86%)
Observational data: associations, not effects.
Further findings
Factors associated with favorable outcome · 24 months
| Comparison | adjusted odds ratio (95% CI) | |
|---|---|---|
| Initial shockable rhythm · covariate-adjusted logistic regression | 3.33 (1.57–7.07) | |
| previous practice of sport · covariate-adjusted logistic regression | 3.13 (1.21–8.12) | |
| prior percutaneous coronary intervention · reduced odds · covariate-adjusted logistic regression | 0.38 (0.17–0.85) | |
| 0.10.31310Adjusted odds ratio (log scale) |
| Outcome | adjusted odds ratio (per 10 years) (95% CI) | |
|---|---|---|
| Factors associated with favorable outcome · 24 months — older age · reduced odds · covariate-adjusted logistic regression | 0.53 (0.41–0.69) | |
| 0.512Adjusted odds ratio (log scale) |
- Factors associated with favorable outcome — Therapeutic hypothermia or acute coronary interventions were not related to prognosis
- P >0.05
Cerebral Performance Category (CPC) trajectories
- remained in CPC1
- 64%
- remained in CPC2
- 13.4%
- improved from CPC2 to CPC1
- 11%
- died either early or lately (>3 months) during follow-up
- 11.6%
- among the 514 patients with at least 3 repeated assessments
- 5 distinct CPC trajectories (2 reflecting early death were combined)
Original publication
Long-Term Neurological Outcome of Out-of-Hospital Cardiac Arrest Survivors and Associated Factors: Results of the DESAC Study, a French Multicentric Prospective Cohort. Circ Popul Health Outcomes. Published 9 April 2026. doi:10.1161/circoutcomes.125.012269
Summarised from the published abstract; every number is checked against it