Heart failure & cardiomyopathies
Long-Term Outcome of ICD Therapy in Patients With Noncompaction Cardiomyopathy Compared With Dilated Cardiomyopathy (DCM) and Hypertrophic Cardiomyopathy (HCM)
Authors' conclusion
At 5 years of follow-up, the rate of appropriate and inappropriate ICD interventions in NCCM was comparable to that in DCM or HCM. In multivariable analysis, no differences in survival were found between the cardiomyopathy groups.
Study context
- Population
- Patients with cardiomyopathy and an ICD, single-centre ICD registry, January 2005 to January 2018
- Participants
- 68 / 458 / 158
- Exposure
- Noncompaction cardiomyopathy (NCCM) vs DCM vs HCM in ICD recipients
- NCCMn = 68
- DCMn = 458
- HCMn = 158
- Outcome
- Appropriate and inappropriate ICD interventions and survival
- Follow-up
- Median 5 years (IQR: 2.0-6.9 years)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Appropriate and inappropriate ICD interventions · median follow-up 5 years
- Appropriate and inappropriate ICD interventions not significantly different between groups
Observational data: associations, not effects.
Further findings
Risk factor for appropriate ICD therapy in NCCM: nonsustained VT on Holter
| HR (95% CI) | ||
|---|---|---|
| Nonsustained VTOnly significant risk factor in NCCM | 5.29 (1.12–24.96) | |
| 0.050.21520Hazard ratio (log scale) |
ICD for primary prevention
- ICD for primary prevention: P = 0.20
Long-term survival
- Significantly better in NCCM in univariable analysis
- No difference between cardiomyopathy groups in multivariable Cox regression
Original publication
Long-Term Outcome of ICD Therapy in Patients With Noncompaction Cardiomyopathy Compared With DCM and HCM. JACC Clin Electrophysiol. Published 22 March 2023. doi:10.
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